Athenex Presents Data on Oral Docetaxel and Oral Paclitaxel at ASCO2021 Virtual Scientific Program
- Data from oral docetaxel phase I pharmacokinetic study shows oral administration can achieve exposure comparable to IV docetaxel
- Post-hoc subgroup efficacy analysis based on updated tumor subtypes in the oral paclitaxel phase III study demonstrated an improved response rate with oral paclitaxel plus encequidar across tumor subgroups
An open label, pharmacokinetic study to determine the bioavailability, safety and tolerability of single dose oral docetaxel (Oradoxel) in metastatic prostate cancer mPC patients treated with IV docetaxel
Abstract 5050; Poster session: Genitourinary Cancer – Prostate, Testicular, and Penile
Data were presented from the open-label, two-way crossover phase I pharmacokinetic study of oral docetaxel vs IV docetaxel, which demonstrated the drug was well tolerated with no dose limiting toxicities, or drug-related serious adverse events. The mean absolute bioavailability was 15.9% (range 8% to 25%) with PK exposure becoming non-linear at 300 mg/m2. Based on these results and the results of other related studies, oral docetaxel 300 mg/m2 as divided doses is being further evaluated.
Confirmed Tumor Response by Molecular Subtype in Patients with Metastatic Breast Cancer (MBC): Sub analysis From a Phase 3 Clinical Study Comparing Oral Paclitaxel and Encequidar to IV Paclitaxel
Abstract 1073; Poster session: Breast Cancer – Metastatic
Updated data were presented from the phase III trial of oral paclitaxel, specifically tumor response rates by receptor subtype.
|N (%)||Oral Paclitaxel plus Encequidar
|Total (ITT)||402||35.8% (95/265)||23.4% (32/137)||12.4%|
|HR+/HER2-||244||28.0% (47/168)||19.7% (15/76)||8.3%|
|HR-/HER2-||57||44.8% (13/29)||21.4% (6/28)||23.4%|
|HER2+||70||49.0% (25/51)||47.4% (9/19)||1.6%|
|HER2 Unknown||31||58.8% (10/17)||14.3% (2/14)||44.5%|
About Athenex, Inc.
Founded in 2003, Athenex, Inc. is a global clinical stage biopharmaceutical company dedicated to becoming a leader in the discovery, development, and commercialization of next generation drugs for the treatment of cancer. Athenex is organized around three platforms, including an Oncology Innovation Platform, a Commercial Platform, and a Global Supply Chain Platform. The Company’s current clinical pipeline is derived from four different platform technologies: (1) Orascovery, based on P-glycoprotein inhibitor, (2) Src kinase inhibition, (3) Cell therapy, and (4) Arginine deprivation therapy. Athenex’s employees worldwide are dedicated to improving the lives of cancer patients by creating more active and tolerable treatments. For more information, please visit www.athenex.com.
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Source: Athenex, Inc.